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This milling force is transferred to the mill feed Through selective contact of the individual granules are created at extremely high inner tensions which lead to fractures The use of the optimal milling force leads to compact mills with extremely low energy requirements

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A mill is a device that breaks solid materials into smaller pieces by grinding, crushing, or cutting Such comminution is an important unit operation in many processesThere are many different types of mills and many types of materials processed in them Historically mills were powered by hand (eg, via a hand crank), working animal (eg, horse mill), wind or water ()

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In this type of mill, the milling media have considerably high energy, because milling stock and balls come off the inner wall of the vial (milling bowl or vial) and the effective centrifugal force reaches up to 20 times gravitational acceleration

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High Pressure Homogenization As described above, wet milling and high pressure homogenization are similar in significant ways Both processes can achieve small particle sizes and offer clear economic advantages and opportunity for scale-up However, the technique for each is distinct As compared to wet milling, high pressure homogenization

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High pressure homogenization is employed for the production of parenteral nutrition emulsions (eg Lipofundin ® and Intralipid ®) High pressure homogenization also enables continuous processing and unlike media milling, contamination problem from milling equipment is much less